Consuelo Gajate Selected Research

edelfosine

12/2021	Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition.
8/2021	Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer.
5/2021	Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.
1/2021	Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release.
4/2018	Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.
8/2017	Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
10/2016	The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.
1/2016	Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy.
11/2015	Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications.
6/2015	Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine.

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Consuelo Gajate Research Topics

Disease

39	Neoplasms (Cancer) 09/2022 - 10/2002
4	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021 - 04/2018
3	Multiple Myeloma 01/2020 - 01/2007
3	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2015 - 02/2009
2	Adenocarcinoma 09/2022 - 04/2018
2	Neoplasm Metastasis (Metastasis) 01/2020 - 01/2016
2	Autoimmune Diseases (Autoimmune Disease) 11/2015 - 10/2002
2	Melanoma (Melanoma, Malignant) 04/2013 - 07/2011
2	Carcinoma (Carcinomatosis) 05/2006 - 02/2004
1	Hypoxia (Hypoxemia) 08/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2018
1	Leishmaniasis 08/2017
1	Infections 10/2016
1	Strongyloidiasis 10/2016
1	Ewing Sarcoma (Sarcoma, Ewing) 06/2015
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/2010
1	Ulcer 05/2009
1	Inflammation (Inflammations) 05/2009
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2009
1	Cardiotoxicity 05/2009
1	Colitis 05/2009
1	Edema (Dropsy) 05/2009
1	Hematologic Neoplasms (Hematological Malignancy) 03/2009
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 02/2009
1	T-Cell Leukemia (Leukemia, T Cell) 01/2009
1	Leukemia 01/2009
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 05/2006

Drug/Important Bio-Agent (IBA)

27	edelfosineIBA 12/2021 - 10/2002
26	LipidsIBA 08/2021 - 10/2002
13	Death Domain ReceptorsIBA 05/2021 - 08/2004
9	Ether (Diethyl Ether)IBA 08/2021 - 10/2002
8	Antineoplastic Agents (Antineoplastics)IBA 08/2021 - 10/2002
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2005
6	Pharmaceutical PreparationsIBA 08/2017 - 11/2005
5	LysophospholipidsIBA 09/2011 - 11/2005
4	TubulinIBA 01/2021 - 01/2005
4	Phospholipids (Phosphatides)FDA LinkGeneric 05/2014 - 10/2002
3	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 10/2002
3	CaspasesIBA 04/2018 - 07/2011
2	Biological ProductsIBA 01/2022 - 10/2002
2	CholesterolIBA 05/2021 - 01/2020
2	Bortezomib (Velcade)FDA Link 01/2020 - 07/2008
2	fosbretabulin (combretastatin A4)IBA 01/2020 - 10/2018
2	Caspase 3 (Caspase-3)IBA 10/2018 - 04/2003
2	perifosineIBA 08/2017 - 01/2007
2	plitidepsin (aplidine)IBA 07/2008 - 04/2003
1	Nicotinamide PhosphoribosyltransferaseIBA 09/2022
1	Epithelial Cell Adhesion MoleculeIBA 12/2021
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2021
1	Arginine (L-Arginine)FDA Link 01/2021
1	IntegrinsIBA 01/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2020
1	Glycoproteins (Glycoprotein)IBA 01/2020
1	Mucin-1 (CA 15-3 Antigen)IBA 01/2020
1	pyridineIBA 01/2020
1	Proteasome InhibitorsIBA 01/2020
1	protein-S-isoprenylcysteine O-methyltransferaseIBA 11/2019
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 10/2018
1	indoleIBA 10/2018
1	Verapamil (Calan)FDA LinkGeneric 10/2018
1	Hydroxyl RadicalIBA 04/2018
1	pyrrolidineIBA 04/2018
1	1-cyano-2,3-epithiopropaneIBA 01/2018
1	miltefosine (Impavido)IBA 08/2017
1	erucylphosphocholineIBA 08/2017
1	1- O- hexadecyl- 2- O- methylglycero- 3- lactoseIBA 01/2016
1	Ion Channels (Ion Channel)IBA 01/2016
1	Therapeutic UsesIBA 01/2016
1	CalciumIBA 04/2013
1	sanguinarineIBA 04/2013
1	Glutathione (Reduced Glutathione)IBA 04/2013
1	Dantrolene (Dantrium)FDA LinkGeneric 04/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2011
1	Apoptosis Inducing FactorIBA 07/2011
1	Adenosine Diphosphate (ADP)IBA 07/2011
1	BerberineIBA 07/2011
1	Cytochromes c (Cytochrome c)IBA 07/2011
1	Adenosine Triphosphate (ATP)IBA 07/2011
1	L-SelectinIBA 05/2009
1	Indomethacin (Indometacin)FDA LinkGeneric 05/2009
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/2009
1	Bentonite (Montmorillonite)IBA 05/2009
1	Apoptosomes (Apoptosome)IBA 03/2009
1	Caspase 8 (Caspase-8)IBA 01/2009
1	DepsipeptidesIBA 07/2008
1	Thalidomide (Thalomid)FDA Link 07/2008
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2008
1	AnthracyclinesIBA 07/2008
1	Alkylating AgentsIBA 07/2008
1	Choline-Phosphate CytidylyltransferaseIBA 05/2006
1	LigandsIBA 03/2005
1	naphthaleneIBA 01/2005
1	Antimitotic AgentsIBA 01/2005
1	AldehydesIBA 02/2004

Therapy/Procedure

15	Therapeutics 01/2022 - 10/2002
7	Drug Therapy (Chemotherapy) 09/2022 - 10/2002
3	Oral Administration 04/2010 - 02/2009
1	Subcutaneous Injections 12/2021